The Church of the Holy Sepulchre is located in the upper part of the Marina district. Documentary sources on its origins are scarce, but the archaeological pre-existence that has come to light below the sacristy describe a sacred area of very ancient origin, witnessed in particular by a circular baptismal basin, datable to late antiquity. The first certain attestation of the existence of the church dates back to 1519. In 1564 it was entrusted by Archbishop Antonio Parragues de Castillejo to the newly established archconfraternity of the Most Holy Crucifix of Prayer and Death, a pious association that governed the church until the middle of the 20th century and whose main purpose was to bury indigent people. Attached to the sacred building was a cemetery, which remained in use until the first decades of the 19th century. After 1564, the church was completely rebuilt, taking on the dimensions and shapes still appreciable today: the first phase, still late Gothic, dates back to the square presbytery, covered by a large five-key star vault, built starting in 1587. The layout of the numerous side chapels that flank the single nave, now embellished with rich wooden and marble furnishings dating back to the 18th century, can also be traced back to the last quarter of the 16th century and the early 17th century. The construction of the new façade on the square in 1899 redefined the entire south side of the building and put in the background the original main façade of the church, now visible on the side alley, characterized by a large circular oculus and the classicistic portal of seventeenth-century style.
On the north side, close to the rock wall, there is the large baroque chapel dedicated to the Virgin of Mercy. It is characterized by the central plan and the impressive octagonal dome and replaced, between 1681 and 1686, a previous domed chapel evidenced by archival sources. The reconstruction of the chapel was designed by the Ligurian master builder Domenico Spotorno and was completed with the financial support of the viceroy of Sardinia Antonio Lopez de Ayala y Velasco, Count of Fuensalida. The large portraits of the viceregal family, by the painter Giuseppe Deris, once hung in the chapel, are now visible in the nearby Museum of the Treasure of Sant'Eulalia. The back wall houses an impressive altarpiece in carved, gilded and polychrome wood, created in the years 1684-1686 by the Majorcan fuster Joan Gabanellas in collaboration with the Neapolitan carver Paolo Spinale and the gilder Bernardo Infante. The central niche houses the fifteenth-century simulacrum of the Virgin of Mercy. At the same time as the factory, under the large octagonal hall, a spacious burial crypt was excavated, which can now be visited, divided into two intercommunicating rooms turned into barrels and characterized by a decoration on the walls that mimic a black funeral drapery.

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